Food safety impacts of antimicrobial use and their residues in aquaculture

Public Health Reviews

Table 1 MRL values for antibiotics in fish according to European Union legislation: Commission Regulation (EU) No 37/2010 of 22 December 2009 [19]

Pharmacologically active substance	Marker residue	MRL (μg kg⁻¹)^a
Sulfonamides (All substances belonging to the sulfonamide group)	Parent drug	100^b
Diaminopyrimidine derivatives Trimethoprims	Parent drug	50
Penicillins
Amoxicillin	Amoxicillin	50
Benzylpenicillin	Benzylpenicillin	50
Cloxacillin	Cloxacillin	300
Dicloxacillin	Dicloxacillin	300
Oxacillin	Oxacillin	300
Quinolones
Oxolinic acid	Oxolinic acid	100
Danofloxacin	Danofloxacin	100
Difloxacin	Difloxacin	300
Enrofloxacin	Sum of enrofloxacin and ciprofloxacin	100
Flumequine	Flumequine	600
Flumequine	Flumequine	150 (salmonidae)
Sarafloxacin	Sarafloxacin	30 (salmonidae)
Macrolides
Erythromycin	Erythromycin A	200
Tilmicosin	Tilmicosin	50
Tylosin	Tylosin A	100
Florfenicol and related compounds
Florfenicol	Florfenicol	1000
Thiamphenicol	Thiamphenicol	50
Tetracyclines
Chlortetracycline	Sum of parent drug and its 4-epimer	100
Oxytetracycline	Sum of parent drug and its 4-epimer	100
Tetracycline	Sum of parent drug and its 4-epimer
Lincosamides
Lincomycin	Lincomycin	100
Aminoglycosides
Spectinomycin	Spectinomycin	300
Neomycin (including framycetin)	Neomycin B	500
Paramomycin	Paramomycin	500
Polymyxins
Colistin	Colistin	150
Nitrofurans		No maximum levels can be fixed

Source: Cañada-Cañada et al. 2009 [14]
^aFor fin fish, these MRLs relate to “muscle and skin in natural proportions”
^bCombined total residues for all substances within the sulfonamide group should not exceed 100 μg kg⁻¹

ISSN: 2107-6952