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Table 1 MRL values for antibiotics in fish according to European Union legislation: Commission Regulation (EU) No 37/2010 of 22 December 2009 [19]

From: Food safety impacts of antimicrobial use and their residues in aquaculture

Pharmacologically active substance Marker residue MRL (μg kg−1)a
Sulfonamides (All substances belonging to the sulfonamide group) Parent drug 100b
Diaminopyrimidine derivatives Trimethoprims Parent drug 50
Penicillins
 Amoxicillin Amoxicillin 50
 Benzylpenicillin Benzylpenicillin 50
 Cloxacillin Cloxacillin 300
 Dicloxacillin Dicloxacillin 300
 Oxacillin Oxacillin 300
Quinolones
 Oxolinic acid Oxolinic acid 100
 Danofloxacin Danofloxacin 100
 Difloxacin Difloxacin 300
 Enrofloxacin Sum of enrofloxacin and ciprofloxacin 100
 Flumequine Flumequine 600
150 (salmonidae)
 Sarafloxacin Sarafloxacin 30 (salmonidae)
Macrolides
 Erythromycin Erythromycin A 200
 Tilmicosin Tilmicosin 50
 Tylosin Tylosin A 100
Florfenicol and related compounds
 Florfenicol Florfenicol 1000
 Thiamphenicol Thiamphenicol 50
Tetracyclines
 Chlortetracycline Sum of parent drug and its 4-epimer 100
 Oxytetracycline Sum of parent drug and its 4-epimer 100
 Tetracycline Sum of parent drug and its 4-epimer  
Lincosamides
 Lincomycin Lincomycin 100
Aminoglycosides
 Spectinomycin Spectinomycin 300
 Neomycin (including framycetin) Neomycin B 500
 Paramomycin Paramomycin 500
Polymyxins
 Colistin Colistin 150
Nitrofurans   No maximum levels can be fixed
  1. Source: Cañada-Cañada et al. 2009 [14]
  2. aFor fin fish, these MRLs relate to “muscle and skin in natural proportions”
  3. bCombined total residues for all substances within the sulfonamide group should not exceed 100 μg kg−1