- Open Access
Preface: Science and Public Health:Professor Ada Yonath, Weizmann Institute of Science, Rehovot, Israel, Nobel Laureate in Chemistry, 2009
Public Health Reviews volume 34, Article number: 2 (2012)
Ribosomes are responsible for translating genetic code into protein and thus central components of cell life. Knowledge of their structure provided important potential applications in and understanding of the mode of action of antibiotics and resistance to antibiotics. The work of Professor Ada Yonath on the crystallography of ribosomes led to improvements in crystallization, crystallographic techniques, and x-ray diffraction detection procedures. In 2000 and 2001, Dr. Yonath published the three dimensional structures of the two subunits of bacterial ribosome. There are potential applications for this work, and hopefully science will use such tools to develop new methods to reduce the burden of many diseases. In 2009, Professor Ada Yonath was awarded the Nobel Prize in Chemistry for her structural work on the ribosome.
Traub W, Yonath A, Segal DM. On the molecular structure of collagen. Nature. 1969;221:914–7.
Arnone A, Bier CJ, Cotton FA, Day Jr VW, Hazen EE, Richardson DC, Richardson JS, Yonath A. A high resolution structure of an inhibitor complex of extracellular nuclease of Staphylococcus aureus. I. Experimental procedures and chain tracing. J Biol Chem. 1971;246:2302–16.
Yonath A, Sielecki A, Moult J, Podjarny A, Traub W. Crystallographic studies of protein denaturation and renaturation. 1. Effects of denaturants on volume and X-ray pattern of cross-linked triclinic lysozyme crystals. Biochemistry. 1977;16:1413–7.
Yonath A, Podjarny A, Honig B, Sielecki A, Traub W. Crystallographic studies of protein denaturation and renaturation. 2. Sodium dodecyl sulfate induced structural changes in triclinic lysozyme, Biochemistry. 1977;16:1418–24.
Traub W, Yonath A, Podjarny A, Sielecki A, Honig B, Moult J. Crystallographic studies of protein folding. J Biophys. 1977;17:A34.
Announcement of the 2009 Nobel Prize in Chemistry. Available from URL: http://www.nobelprize.org/mediaplayer/index.php?id=1168 (Accessed 24 May 2013).
Appelt K, Dijk J, Reinhardt R, Sanhuesa S, White SW, Wilson KS, Yonath A. The crystallization of ribosomal proteins from the 50S subunit of the Escherichia coli and Bacillus stearothermophilus ribosome. J Biol Chem. 1981;256:11787–90.
Yonath A, Leonard KR, Wittmann HG. A tunnel in the large ribosomal subunit revealed by three-dimensional image reconstruction. Science. 1987;236:813–6.
Hope H, Frolow F, von Boehlen K, Makowski I, Kratky C, et al. Cryocrystallography of Ribosomal Particles. Acta Crystallogr B. 1989;45:190–9.
Schluenzen F, Tocilj A, Zarivach R, Harms J, Gluehmann M. D. et al. Structure of functionally activated small ribosomal subunit at 3.3 A resolution. Cell. 2000;102:615–23.
Harms J, Schluenzen F, Zarivach R, Bashan A, Gat S, et al. High resolution structure of the large ribosomal subunit from a mesophilic eubacterium. Cell. 2001;107:679–88.
Bashan A, Agmon I, Zarivach R, Schluenzen F, Harms J, et al. Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression. Mol Cell. 2003;11:91–102.
Schluenzen F, Zarivach R, Harms J, Bashan A, Tocilj A, et al. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001;413:814–21.
Davidovich C, Belousoff MJ, Wekselman I, Shapira T, Krupkin M, et al. The proto-ribosome: an ancient nano-machine for peptide bond formation. Isr J Chem. 2010;50:29–35.
About this article
Cite this article
Leighton, L. Preface: Science and Public Health:Professor Ada Yonath, Weizmann Institute of Science, Rehovot, Israel, Nobel Laureate in Chemistry, 2009. Public Health Rev 34, 2 (2012) doi:10.1007/BF03391670
- Nobel Prize Chemistry 2009
- Professor Ada Yonath
- Weizman Institute Israel
- x-ray crystallography
- antibiotic resistance
- science and public health